Zaynab bint Khuzayma, Umm al Muminin, was also her half-sister. Her other sisters included Asma bint Umays, the wife of Ja'far ibn Abi Talib, who later married Abu Bakr, and Salma bint Umays, the wife of Hamza, the "Lion of Allah". Her full sisters were Lubaba, Asma and Izza. Maymuna was thus one of the 'Ahlul- Bayt' , 'the people of the House', not only by virtue of being a wife of the Prophet, (peace and blessings of Allah be upon him) but also because she was related to him. Zayd bin Arqam related that the Messenger of Allah (peace and blessings of Allah be upon him) said, "I implore you by Allah! The People of my House!" three times. Zayd was asked who were the People of the House, and he said, "The family of Ali ibn Abi Talib, the family of Jafar ibn Abi Talib, the family Aqil ibn Abi Talib, and the family of Al Abbas ibn Abdal Muttalib."

Maymuna or Barra as she was then called, yearned to marry the Prophet. She went to her sister, Umm al Fadl to talk to her about that and she, in turn, spoke to her husband, al-Abbas. Al-Abbas immediately went to the Messenger (peace and blessings of Allah be upon him) with Maymuna's offer of marriage to him and her proposal was accepted. When the good news reached her, she was on a camel, and she immediately got off the camel and said, "The camel and what is on it is for the Messenger of Allah (peace and blessings of Allah be upon him)." They were married in the month of Shawwal in 7 AH just after the Muslims of Medina were permitted to visit Mecca under the terms of the treaty of Hudaybiyya to perform umra. Allah Almighty sent the following ayat about this:

The Prophet gave her the name, Maymuna, meaning "blessed", and Maymuna lived with the Prophet for just over three years, until his death. She was obviously very good natured and got on well with everyone, and no quarrel or disagreement with any of the Prophet's other wives has been related about her. 'A'isha said about her, "Among us, she had the most fear of Allah and did the most to maintain ties of kinship." It was in her room that the Prophet first began to feel the effects of what became his final illness and asked the permission of his wives to stay in A'isha's room while it lasted.

After the Prophet's death, (peace and blessings of Allah be upon him) Maymuna continued to live in Medina for another forty years, dying at the age of eighty, in 51 AH, (may Allah be pleased with her), being the last but one of the Prophet's wives to die. She asked to be buried where had married the Prophet at Saraf and her request was carried out. It is related that at the funeral of Maymuna, Ibn Abbas said, "This is the wife of Allah's Messenger, (peace and blessings of Allah be upon him) so when you lift her bier, do not shake her or disturb her, but be gentle." It is also related by Ibn Abbas that he once stayed the night as a guest of Maymuna, who was his aunt, and the Prophet, (peace and blessings of Allah be upon him) They slept on their blanket lengthways and he slept at the end, crossways. After they had all slept for awhile, the Prophet rose in the middle of the night to pray the tahajjud prayer, and Ibn Abbas joined him.

They both did wudu, and he prayed eleven rakats with the Prophet (peace and blessings of Allah be upon him). Then they both went back to sleep again until dawn. Bilal called the adhan, and the Prophet did another two short rakats, before going into the mosque to lead the Dawn Prayer.

Ibn Abbas said that one of the dua'ahs that the Prophet made during this night was : "O Allah, place light in my heart, light in my tongue, light in my hearing, light on my sight, light behind me, light in front of me, light on my right, light on my left, light above me and light below me; place light in my sinew, in my flesh, in my blood, in my hair and in my skin; place light in my soul and make light abundant for me; make me light and grant me light."

It is commonly agreed that it was after the Prophet had married Maymuna, giving him now nine wives (A'isha, Sawda, Hafsa, Umm Salama, Zainab bint Jahsh, Juwayriyya, Umm Habiba, Safiyya and Maymuna), that the following ayat was revealed:

After this, the Prophet (peace and blessings of Allah be upon him) did not marry again. When however, the Christian ruler, or Muqawqis, of Egypt, sent him two Christian slave girls 0 who were sisters as a gift (in response to the Prophet's letter inviting him to embrace Islam), along with a fine robe and some medicine the Prophet, accepted one of the slave girls, Maria, into his household; he gave her sister Serene, to a man whom he wished to honor, namely Hassan ibn Thabit; he accepted the robe; and he returned the medicine with the message, "My Sunna is my medicine!" This occurred in 7 AH, when the Prophet wassixty years old and Maria was twenty years old.